XL TET2

The myelodysplastic syndromes and myeloproliferative disorders are associated with deregulated production of myeloid cells. According to WHO classification (2008) cytogenetic aberrations are observed in about 50% of MDS cases. The most common aberrations are 5q-, 7/7q-, Trisomie 8, del(20q), and inv(3) or t(3,3).

Recently a new deletion not yet listed in the WHO classification has been identified del(4q24) involving the tumor suppressor gene TET2.

The XL TET2 locus-specific probe detects deletions in 4q24. This probe is labeled in orange and spans from marker R 43141 to RH69608 proximal and distal to the TET2 gene. A green labeled probe specific to 4q12 functions as a reference probe.

Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of tumors. Deletions in 6q occur in 7% of B-CLL and a minimal critical region between 6q21-6q23 has been described. More recently a commonly deleted region of 4-5 Mb has been described also in the pathogenesis of both low and high grade NHL and ALL. The XL 6q21/6q23 locus-specific probe detects deletions in the two regions at the long arm of chromosome 6. The green labeled probe detects a specific region at 6q21 including the SEC63 gene. The labeled probe hybridizes specifically to the MYB gene region at 6q23. orange.

XL 6q21/6q23 hybridized to a normal metaphase. Orange signals represent the MYB gene region at 6q23, the green signals are located at 6q21 and include the SEC63 gene region.