XL TET2 4q24 specific deletion probe		XI TET2 hybridized to a normal metaphase. Orange signals represent the TET2 gene region at 4q24, the green control signals are located at 4Q12 and include the SCFD2 gene region.

Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphiod malignancies and have been identified as adverse prognostic factor in subsets of tumors.

Deletions in 6q occur in 7% of B-CLL and a minimal critical region between 6q21-6q23 has been described. More recently a commonly deleted region of 4-5 Mb has been described also in the pathogenesis of both low and high grade NHL and ALL.

The XL 6q21/6q23 locus-specific probe detects deletions in the two regions at the long arm of chromosome 6.

The green labeled probe detects a specific region at 6q21 including the SEC63 gene. The labeled probe hybridizes specifically to the MYB gene  region at 6q23.

XL6q21/6q23 6q21 and 6q23 specific deletion probe.		XI 6q21/6q23 hybridized to a normal metaphase.Orange signals represent the MYB gene region at 6q23, the green signals are located at 6q21 and include the SEC63 gene region.